Inhibition of Heat Shock Protein 70 and 90 (Hsp70 And Hsp90) in Target Spesific Cancer Treatment
نویسنده
چکیده
Volume 3 • Issue 2 • 1000e109 Adv Tech Biol Med ISSN: 2379-1764 ATBM, an open access journal Hsp70 (70 kDa) and Hsp90 (90 kDa) are important members of the chaperone protein family. They are over-expressed in a wide range of tumor types (both solid tumors and hematological malignancies), and play essential roles in apoptosis, cell proliferation, metastases, angiogenesis, and invasion pathways in cancer cell metabolism. Hsp70 and Hsp90 provide stabilization; regulation and maintenance of oncogenic client proteins (Her-2, Cdk-4, Akt, Raf-1) thus promote cancer cell survival. Therefore, inhibition of Hsps was accepted potential therapeutic strategy for cancer for the last two decades [1,2].
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تاریخ انتشار 2015